Endocrine Abstracts

Introduction: Idiopathic Isolated Adrenocorticotropic hormone (ACTH) deficiency (IIAD) is a rare cause of secondary adrenal insufficiency. It can present with a variety of clinical symptoms, mainly chronic fatigue and euvolemic hyponatraemia, and may coexist with autoimmune disease, most commonly Hashimoto’s thyroiditis. Radiographically, an empty sella turcica image can be seen. We present 3 cases of isolated ACTH deficiency.Case 1: A 47-year-old w...

Introduction: PD-1 inhibitors are powerful disruptors of self- tolerance and autoimmune diabetes develops in up to 0.9% of patients. Lipodystrophic insulin reactions, although uncommon with human insulin analogs, are a recognized cause of impaired insulin delivery in patients on intensive insulin regimens. We describe a patient with resistant lymphoma and nivolumab-induced autoimmune diabetes, who suffered loss of glycemic control due to early radiation-induced subcutaneous fi...

Background: The mechanisms regulating adrenarche have not been elucidated, although evidence supports a critical role for ACTH and possibly other unidentified pituitary or adrenal contributing factors. Absent adrenarche has been described in children with a variety of sellar tumors. We describe a case series of five adults with congenital hypopituitarism and absent adrenarche.Cases: Three females and two males with “idiopathic” congenital hypop...

Introduction: Empty sella syndrome (EES) is a condition often discovered incidentally, where the sella turcica, the structure containing the pituitary gland, appears to be empty. Patients either remain asymptomatic or, rarely, manifest signs of declined pituitary function. Patients experiencing hypopituitarism are offered hormonal replacement. Autopsy studies estimated a 5% EES prevalence among healthy individuals.Case report: A 68-year-old post-menopaus...

Introduction: Cushing’s syndrome is a rare (0.004%) hormonal disorder, which develops due to hypercortisolaemia. Cushing’s disease refers to a corticothroph cell pituitary tumour overproducing ACTH, which induces abnormally increased cortisol production from the adrenal glands. Cushing’s disease is a causative factor of osteoporosis, hypertension, glucose intolerance and dyslipidaemia.Case report: A 50-year old woman was referred to our de...